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doi: 10.1016/j.tox.2013.03.008

In order to translate observed breathing patterns and smoking behavior into biological effects, we combined the small airway-on-a-chip with a smoking machine that burns cigarettes and a microrespirator that inhales and exhales small volumes of cigarette smoke and fresh air in and out of the epithelium-lined channel in programmable intervals mimicking true smoking behavior, said Richard Novak, a co-author of the study and a senior staff engineer at the Wyss Institute, who helped design the smoking instrument

[213] Viscusi, W

population smoked, and most of the other half accepted the practice as socially acceptable

At concentrations of one cigarette butt per litre of water, the toxins are lethal to small fish, and to planktonic organisms such as water fleas at one-eighth of this concentration